Period Covered: 15 April 2015 – 15 March 2015
Mouse Study Suggests Immune Disorder May Play Role in Alzheimer’s
If seen in humans, it might lead to new treatments for memory-robbing disease
Duke University researchers found that in a mouse model of Alzheimer’s, something goes wrong with certain immune cells that normally protect the brain, and the cells start to consume an important nutrient called arginine. In mice, treatment with a drug called difluoromethylornithine (DFMO) blocked these immune cells from consuming arginine and prevented the brain plaques and memory loss associated with Alzheimer’s.
Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease
NIH-supported research enables clinical trial to explore treatment for most common form of dementia
Scientists have found that a compound originally developed as a cancer therapy potentially could be used to treat Alzheimer’s disease. The team demonstrated that the drug, saracatinib, restores memory loss and reverses brain problems in mouse models of Alzheimer’s, and now the researchers are testing saracatinib’s effectiveness in humans. The study was funded by the National Institutes of Health as part of an innovative crowdsourcing initiative to repurpose experimental drugs.
Could a Diet Help Shield You From Alzheimer’s?
Scientists say the MIND eating plan significantly reduces risk of the brain disorder
The eating plan emphasizes healthy grains, vegetables, beans, poultry and fish while also allowing for a limited amount of less healthy red meat, butter and sweets. The MIND diet combines aspects of the better-known Mediterranean diet with certain features of the so-called DASH (Dietary Approaches to Stop Hypertension) diet, both of which call for high consumption of fruits, vegetables, and fish.
Many With Alzheimer’s Aren’t Told of Diagnosis by Doctor: Report
Researchers found patients were more likely to be informed only after their disease had advanced
Doctors are not telling a majority of their patients diagnosed with Alzheimer’s that they have the degenerative brain disease, a new report shows. The research, conducted by the Alzheimer’s Association, involved patients whose Medicare records listed treatments that are specific to Alzheimer’s disease. However, when the researchers asked the patients (or a caregiver as a proxy) if their doctor had informed them that they had the brain-robbing disease, only 45 percent said they had been told so by their doctor.
Researchers Pinpoint Possible Protein Culprit Behind Alzheimer’s
Postmortem analysis of almost 1,400 brains implicates tau, not amyloid, buildup driving memory loss
Abnormal tau protein collecting in the brain may be the main cause of Alzheimer’s disease, a new study claims. Another protein called amyloid accumulates as Alzheimer’s progresses, but is not the primary culprit behind the devastating memory loss that is the hallmark of the disease, Mayo Clinic researchers report.